Lisle Homes for Sale lies within the watershed of DuPage River. Don’t forget to get market insiders by calling Patrick! Lisle is a village in DuPage County, Illinois, United States and most of the village lies within the watershed of the east branch of the DuPage River. Total population of Lisle is 22,687 as per city data. Lisle is the headquarters of the Nuclear Regulatory Commission Region III and Lisle was ranked number 17 Money magazine’s list of the “Best Places for the Rich and Single” in 2009. Lisle has a total area of 7.02 square miles, of which 6.84 square miles is land and 0.18 square miles is water.